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Fda is requiring all manufacturers of all prescription nsaid pain relievers including medications like ibuprofen motrin , celecoxib celebrex , and naproxen naprosyn to include updated safety language within their product labels.

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Advise patients to be alert for the symptoms of congestive heart failure including shortness of breathunexplained weight gainor edema and to contact their healthcare provider if such symptoms occursee WARNINGS AND PRECAUTIONS

Exactly as prescribed at the lowest dose possible for your treatment for the shortest time needed.

Alternative therapies for treatment of JRA should be considered in pediatric patients identified to be CYP2C9 poor metabolizerssee Poor Metabolizers of CYP2C9 substrates

The Coxib and traditional NSAID TrialistsCollaboration meta-analysis of randomized controlled trials demonstrated an approximately twofold increase in hospitalizations for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patientsIn a Danish National Registry study of patients with heart failureNSAID use increased the risk of MIhospitalization for heart failureand death.

The following adverse reactions are discussed in greater detail in other sections of the labeling:

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