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Concomitant use of the following other medicinal products cannot be recommended:
Excipient(sof known effectseach hard capsule also contains 149.12 mg lactose monohydrate.
Fluconazole inhibits CYP2C9CYP2C19and CYP3A4 isoenzymescoadministration with drugs that are substrates if these isoenzymes may be contraindicated or warrant dosage modifications.
TacrolimusFluconazolemay increase the serum concentrations of orally administered tacrolimus up to 5 times due to inhibition of tacrolimus metabolism through CYP3A4 in the intestinesNo significant pharmacokinetic changes have been observed when tacrolimus is given intravenouslyIncreased tacrolimus levels have been associated with nephrotoxicityDose of orally administered tacrolimus should be decreased depending on tacrolimus concentration.
In light of the recent research and continued reviewwe find it necessary to add fluconazolea.k.aDiflucanto the list of potentially dangerous medications.
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